Delicious Artichoke and Parmesan Tilapia Recipe (Quick, Healthy & Crispy)

If you’re looking for a go-to dinner that’s fast, healthy, and full of flavor, this Artichoke and Parmesan Tilapia Recipe delivers all that and more. It’s crispy on top, flaky inside, and finished in under 20 minutes. Whether you’re new to cooking or need a no-fail meal that impresses, this dish checks every box. With just a few pantry staples, the Artichoke and Parmesan Tilapia Recipe transforms weeknight cooking into something truly satisfying. Plus, it’s naturally low-carb, high-protein, and perfect for keto or gluten-free lifestyles.

I first created this Artichoke and Parmesan Tilapia Recipe when I needed something quick, healthy, and satisfying after a long stretch of dealing with health challenges. I was craving comfort food but without the heaviness and this recipe checked every box. It’s light, flavorful, and packed with protein, which is exactly what I needed to stay on track while still enjoying what I eat.

Now, it’s a staple in our home for a reason it proves that healthy eating can feel like a treat, and even my discerning cat, Luna, agrees!

Table of Contents

Why This Recipe is a Weeknight Winner

Print

This Artichoke and Parmesan Tilapia Recipe is everything you want in a fast, flavorful dinner. It bakes in just 15–20 minutes, broils to a crispy golden finish in under 10, or air-fries to perfection in 12. No matter how you cook it, the fish comes out tender and flaky, with a beautifully crisp topping that feels indulgent but isn’t.

And the best part? It’s naturally low-carb, high in protein, and gluten-free. That means it fits into keto and healthy eating plans effortlessly, without compromising flavor. It’s satisfying, simple, and makes clean eating feel like a treat. Pair it with something fun like this Greek yogurt cookie dough treat for dessert.

What You’ll Need for This Artichoke and Parmesan Tilapia Recipe

Simple Ingredients, Big Flavor
You don’t need a long list of items to create this crave-worthy tilapia dish. Each ingredient brings real flavor and purpose no fluff, just fresh, clean, satisfying results.

• Tilapia fillets (1 lb) – Mild, flakey, and protein-rich. The ideal foundation for building a crispy, flavorful crust.
• Chopped artichoke hearts (6 oz) – Rinse and drain to remove brine. They add a bright, tangy layer that pairs perfectly with cheese and herbs.
• Grated Parmesan cheese (¼ cup) – Freshly grated works best for melt, flavor, and a beautiful golden top.
• Almond flour (¼ cup) – These low-carb, gluten-free alternatives give you a crispy topping without the carbs. (For a traditional texture, see the Notes section.)
• Lemon juice (1 tsp) – Adds acidity and balance, lifting the dish with a clean citrus note.
• Dried oregano (1 tsp) – Brings a familiar Italian flavor profile that complements both fish and cheese.
• Salt & pepper – A little goes a long way. Be sure to season both sides of the fillets before topping.

💡 Want to make this dish even more flavorful? Try pairing it with something fresh and zesty like our Greek yogurt sriracha sauce or a vibrant side like the sweet potato burger bowl.

Equipment You’ll Need (No Fancy Tools Required)

This easy tilapia recipe is all about keeping things simple. You likely have everything already:

• Rimmed baking sheet – Line with parchment paper for easy cleanup.
• Olive oil mister or non-stick spray – Lightly coat to prevent sticking.
• Mixing bowl – To combine the topping ingredients.
• Spatula or fork – For testing doneness (fish should flake easily).
• Optional: Air fryer – A fast and crispy option with no added oil.

Need more quick, low-prep ideas? You might also enjoy this avocado toast with scrambled egg for breakfast-for-dinner nights.

Step-by-Step Instructions for the Perfect Bake

Here’s how to cook it perfectly every time:

1. Preheat oven to 375°F. Line a rimmed baking sheet with parchment paper and mist with olive oil spray.
2. Season the fish – Pat each tilapia fillet dry with paper towels. Season both sides with salt and pepper.
3. Mix the topping – In a bowl, combine chopped artichoke hearts, Parmesan cheese, whole wheat breadcrumbs, lemon juice, and oregano.
4. Top the tilapia – Spoon the mixture over each fillet evenly, pressing gently to help it stick.
5. Bake for 15–20 minutes – Fish is done when it flakes easily with a fork and topping is lightly golden.

That’s it! You’ve just created a restaurant-worthy dinner with minimal effort and maximum flavor.

Cooking Methods: Bake, Broil, or Air Fry!

One of the best things about this Artichoke and Parmesan Tilapia Recipe is its flexibility. Whether you’re craving a baked fish dinner, a crispy broiled finish, or need something lightning-fast in the air fryer, this recipe works perfectly every way.

Baked Artichoke and Parmesan Tilapia (Classic & Reliable)
The baked version of this Artichoke and Parmesan Tilapia Recipe is the go-to method for most home cooks. It’s simple, mess-free, and ideal when you want a set-it-and-forget-it meal.

• Prep: Preheat oven to 375°F.
• Cook Time: 15–20 minutes.
• Tip: Place fillets on the middle rack for even cooking. Don’t overbake tilapia should flake easily with a fork when done.

The artichoke topping turns beautifully golden, while the fish stays moist and flakey. Serve with a side like this sweet potato burger bowl for a complete meal.

Broiled Parmesan Tilapia (Extra Crispy Top)
If you want that cheesy, bubbly crust, broiling is your method. This Artichoke and Parmesan Tilapia turns crisp on top while remaining juicy inside.

• Prep: Set oven to broil and position rack 5–6 inches from the heat source.
• Cook Time: 6–8 minutes, depending on fillet thickness.
• Tip: Watch closely broilers cook fast. The topping should bubble and turn golden brown.

Pair it with something cooling like this vegan fruit dip for a refreshing contrast.

Air Fryer Parmesan Tilapia (Fast & Healthy)
For a quicker version of this Artichoke and Parmesan Tilapia Recipe, the air fryer delivers. You’ll get a crispy finish with zero hassle.

• Prep: Preheat air fryer to 375°F. Lightly spray basket with oil.
• Cook Time: 10–12 minutes.
• Tip: Don’t overcrowd cook in batches if needed.

This is the ideal method for busy weeknights, giving you crisp texture and no cleanup. It also keeps the dish low in oil and carbs, making it a standout keto tilapia recipe.

With three easy ways to cook it, there’s no reason not to try this Artichoke and Parmesan Tilapia Recipe tonight!

Tips for Perfect Results + Ingredient Swaps

This Artichoke and Parmesan Tilapia Recipe is already simple, but a few smart tips and creative ingredient swaps will take your results from good to unforgettable.

Pro Tips for Success

• Pat the tilapia dry – This ensures the topping adheres well and prevents sogginess.
• Use freshly grated Parmesan – Pre-shredded cheese doesn’t melt or crisp up as nicely.
• Don’t skip the lemon juice – It cuts through the richness and balances the flavors.
• Fold thin fillet edges – Helps even out cooking if fillets vary in thickness.
• Watch your timing – Tilapia is done when it flakes easily with a fork. Overcooking will dry it out.
• Reheat properly – Reheat at 300°F in an oven or toaster oven for 5–7 minutes to restore crispness without overcooking the fish.

If you’re storing leftovers, use an airtight container and reheat gently in the oven not the microwave to maintain texture. Serve it with reheatable sides like the ground beef protein bowl to round out the meal.

Ingredient Substitutions & Add-Ins
The beauty of this Artichoke and Parmesan Tilapia Recipe is how easily it adapts.

No Parmesan?
Try shredded Asiago, Romano, or even nutritional yeast for a dairy-free twist.

Gluten-Free or Keto?
Swap breadcrumbs for almond meal, or leave them out entirely this becomes a perfect low-carb tilapia recipe either way.

Don’t Have Tilapia?
Cod, halibut, or even salmon all work beautifully here. Just adjust your cook time based on thickness.

Want more punch?
Add chopped sun-dried tomatoes, crushed red pepper flakes, or a few capers to your artichoke mix. Or try topping with a drizzle of Greek yogurt sriracha sauce after baking for extra zing.

Once you’ve made this Artichoke and Parmesan Tilapia Recipe once, you’ll find yourself riffing on it with your own twist in no time.

Final Thoughts

This Artichoke and Parmesan Tilapia Recipe is everything I believe weeknight cooking should be: simple, healthy, adaptable, and full of flavor. With options to bake, broil, or air fry, you can make it your own with what you have and how you like to cook. Serve it with a crisp salad, roasted veggies, or something heartier like the sweet potato burger bowl for a satisfying, feel-good dinner.

Whether you’re eating low-carb, cooking for family, or just want a no-fail fish dinner, this one’s a keeper.

For More Recipes Follow me in Facebook and Pinterest

Frequently Asked Questions About Cooking Tilapia